Redeploying β-Lactams AgainstStaphylococcus aureus:Repurposing With a Purpose
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چکیده
منابع مشابه
High Serum β-Lactams Specific/Total IgE Ratio Is Associated with Immediate Reactions to β-Lactams Antibiotics
Total serum IgE result from the combination of specific and non-specific pools. High specific/total IgE ratio may reflect high level of allergen-specific IgE on mast cells. No data regarding its applications to drug allergies is available. One hundred seventy-one patients with a history of immediate reactions to β-lactams, confirmed by positive skin testing, and 122 control subjects tolerant to...
متن کاملDe-Escalating Anti-Pseudomonal β-Lactams
Methods We retrospectively included all ICU episodes in Ghent University Hospital during 2013 and 2014 with prescription of meropenem, piperacillin-tazobactam or ceftazidime for at least 48 hours, stratifying between ICU episodes of < and ≥4 days; for outcome analysis, only the first ≥4 days episode per patient was included. Deescalation was defined as a change from meropenem to a non-carbapene...
متن کاملConsequences of avoiding β-lactams in patients with β-lactam allergies.
BACKGROUND The choice of empiric antibiotics for the treatment of gram-negative bacilli (GNB) bloodstream infections (BSIs) in patients presenting with a β-lactam (BL) allergy is often a difficult decision given that these agents are first-line treatment in many guidelines. OBJECTIVE We sought to compare rates of clinical failure between patients with a history of BL allergy who received eith...
متن کاملSystematic Review of Professional Liability when Prescribing Β-Lactams for Patients with a Known Penicillin Allergy
OBJECTIVE To describe medical negligence and malpractice cases in which a patient with a known penicillin allergy received a beta-lactam and experienced an adverse reaction related to the beta-lactam. DATA SOURCES Lexis-Nexus, Westlaw, and Google Scholar were searched. STUDY SELECTIONS Medical negligence and malpractice cases were eligible for inclusion if they met the following criteria: t...
متن کاملInteractions of OP0595, a Novel Triple-Action Diazabicyclooctane, with β-Lactams against OP0595-Resistant Enterobacteriaceae Mutants.
OP0595 is a novel diazabicyclooctane which, like avibactam, inhibits class A and C β-lactamases. In addition, unlike avibactam, it has antibacterial activity, with MICs of 0.5 to 4 μg/ml for most members of the family Enterobacteriaceae, owing to inhibition of PBP2; moreover, it acts synergistically with PBP3-active β-lactams independently of β-lactamase inhibition, via an "enhancer effect." En...
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ژورنال
عنوان ژورنال: Journal of Infectious Diseases
سال: 2016
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/jiw464